John C Alverdy Selected Research

Intraoperative Complications

11/2022	Defining Microbiome Readiness for Surgery: Dietary Prehabilitation and Stool Biomarkers as Predictive Tools to Improve Outcome.
6/2020	Spatial Compartmentalization of the Microbiome between the Lumen and Crypts Is Lost in the Murine Cecum following the Process of Surgery, Including Overnight Fasting and Exposure to Antibiotics.
1/2020	An in vitro tissue model for screening sustained release of phosphate-based therapeutic attenuation of pathogen-induced proteolytic matrix degradation.
1/2019	Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.
11/2018	Ionic Modulation of Bacterial Virulence and Its Role in Surgical Infection.
1/2018	Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis".
1/2017	De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly(Ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas aeruginosa as a Model Intestinal Pathogen.
1/2013	The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis.
2/2012	Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration.
11/2011	Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption.

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John C Alverdy Research Topics

Disease

16	Sepsis (Septicemia) 01/2021 - 02/2004
13	Critical Illness (Critically Ill) 12/2020 - 06/2006
11	Intraoperative Complications 11/2022 - 09/2011
11	Anastomotic Leak 12/2021 - 01/2012
7	Infections 12/2021 - 09/2011
6	Ischemia 11/2018 - 05/2011
5	Starvation 11/2022 - 01/2017
5	Neoplasms (Cancer) 01/2022 - 04/2013
5	Wounds and Injuries (Trauma) 01/2022 - 04/2013
4	Necrosis 08/2012 - 07/2011
4	Morbid Obesity 08/2010 - 03/2006
4	Weight Loss (Weight Reduction) 07/2010 - 09/2006
3	Wound Infection (Wound Infections) 01/2022 - 04/2015
3	Hypoxia (Hypoxemia) 06/2020 - 01/2007
3	Obesity 01/2019 - 03/2009
3	Inflammation (Inflammations) 02/2018 - 02/2012
2	Colonic Neoplasms (Colon Cancer) 01/2022 - 01/2020
2	Surgical Wound Infection 01/2022 - 01/2017
2	Colitis 01/2016 - 06/2010
2	Necrotizing Enterocolitis 08/2012 - 02/2012
2	Gastroesophageal Reflux (GERD) 08/2010 - 03/2010
2	Vomiting 03/2010 - 02/2008
1	Infertility (Sterility) 01/2022
1	Rectal Neoplasms (Rectal Cancer) 01/2021
1	Bacteremia 12/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/2020
1	Non-alcoholic Fatty Liver Disease 09/2020
1	Alcoholic Fatty Liver 09/2020
1	Carcinoma (Carcinomatosis) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2020
1	Carcinogenesis 01/2020
1	Weight Gain 01/2019
1	Burns 04/2017
1	Crush Injuries 01/2017
1	Cerebral Palsy (Spastic Diplegia) 01/2016
1	Ulcerative Colitis 01/2016
1	Pouchitis 01/2016

Drug/Important Bio-Agent (IBA)

19	Anti-Bacterial Agents (Antibiotics)IBA 11/2022 - 06/2006
6	Collagenases (Collagenase)FDA Link 01/2022 - 05/2015
6	Phosphates (Orthophosphate)IBA 01/2022 - 09/2011
4	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2014 - 02/2004
3	PolymersIBA 01/2022 - 02/2010
3	CollagenIBA 12/2020 - 05/2015
3	Butyrates (Butyrate)IBA 12/2020 - 06/2020
3	Pharmaceutical PreparationsIBA 11/2020 - 06/2006
3	CytokinesIBA 11/2018 - 02/2003
3	IronIBA 01/2017 - 09/2011
2	PlasminogenIBA 01/2022 - 12/2021
2	Volatile Fatty AcidsIBA 12/2020 - 09/2012
2	Bile Acids and Salts (Bile Acids)IBA 09/2020 - 11/2011
2	PolyphosphatesIBA 01/2020 - 01/2018
2	Opioid Analgesics (Opioids)IBA 11/2018 - 09/2014
2	SiderophoresIBA 01/2017 - 09/2011
2	Proteins (Proteins, Gene)FDA Link 03/2014 - 01/2007
2	AcidsIBA 09/2012 - 03/2006
2	LectinsIBA 01/2007 - 01/2005
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2022
1	Drinking WaterIBA 01/2022
1	ElementsIBA 01/2022
1	Tranexamic Acid (AMCA)FDA Link 12/2021
1	SolutionsIBA 12/2021
1	Dietary Fiber FDA Link 01/2021
1	Interferon Regulatory FactorsIBA 11/2020
1	Tumor Necrosis Factor InhibitorsIBA 11/2020
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 11/2020
1	Peptide Hydrolases (Proteases)FDA Link 01/2020
1	16S Ribosomal RNAIBA 01/2020
1	Amino Acids FDA Link 02/2018
1	FatsIBA 02/2018
1	ChemokinesIBA 02/2018
1	CarbohydratesIBA 02/2018
1	ElectrolytesIBA 02/2018
1	N 30IBA 01/2017
1	SmokeIBA 01/2017
1	acinetobactinIBA 01/2017
1	Nicotine FDA Link 01/2016
1	Interleukin-10 (Interleukin 10)IBA 01/2016
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2015
1	Biological ProductsIBA 10/2014
1	Cytotoxins (Cytolysins)IBA 10/2013

Therapy/Procedure

9	Bariatric Surgery 09/2020 - 03/2006
8	Therapeutics 12/2020 - 02/2010
8	Gastric Bypass (Roux-en-Y Gastric Bypass) 08/2010 - 09/2006
5	Hepatectomy 11/2022 - 01/2013
3	Fecal Microbiota Transplantation 01/2021 - 11/2020
2	Ileostomy 01/2021 - 06/2010
2	Ligation 01/2020 - 01/2017
2	Critical Care (Surgical Intensive Care) 02/2018 - 12/2011
2	Enteral Nutrition (Feeding, Tube) 01/2017 - 02/2012
2	Colectomy 01/2016 - 06/2010
2	Biliopancreatic Diversion 08/2010 - 10/2006
1	Rehabilitation 11/2022
1	Length of Stay 11/2021
1	Enema (Enemas) 01/2020
1	Punctures 01/2020
1	Operative Surgical Procedures 01/2019
1	Nutritional Support (Artificial Feeding) 02/2018
1	Transplantation 01/2017
1	Resuscitation 05/2016
1	Surgical Staplers (Surgical Stapler) 09/2013